Article
Human CD19 and CD40L deficiencies impair antibody selection and differentially affect somatic hypermutation.
The Journal of allergy and clinical immunology - 1 Jul 2014
van Zelm Menno C, Bartol Sophinus J W, Driessen Gertjan J, Mascart Françoise, Reisli Ismail, Franco Jose L, Wolska-Kusnierz Beata, Kanegane Hirokazu, Boon Louis, van Dongen Jacques J M, van der Burg Mirjam
Abstract excerpt
BACKGROUND: Individuals with genetic defects in CD40 ligand (CD40L) or B-cell antigen receptor coreceptor molecules CD19 and CD81 suffer from an antibody deficiency. Still, these patients carry low levels of memory B cells and serum antibodies. OBJECTIVE: We sought to assess why the remaining memory B cells and antibodies in the blood of these patients do not provide functional immunity. METHODS: We included...
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