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Article

Trapping distinct structural states of a protein/DNA interaction through disulfide crosslinking.

Chemistry & biology - 1 Dec 2002

He Chuan, Verdine Gregory L

Abstract excerpt

The N-terminal domain of the Escherichia coli Ada protein (N-Ada) repairs methyl phosphotriesters in DNA through a zinc-mediated transfer to Cys38 of the protein. Methylation of Cys38 enhances the sequence-specific DNA affinity of N-Ada by approximately 1000-fold, thereby enabling the protein to activate the genes of a methylation-resistance regulon. It is of interest to understand the structural basis for...

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PMID: 12498882
DOI: 10.1016/s1074-5521(02)00283-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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