BCL-2 promotes migration and invasiveness of human glioma cells.

doi:10.1016/s0014-5793(98)01494-x

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Article

BCL-2 promotes migration and invasiveness of human glioma cells.

FEBS letters - 4 Dec 1998

Wick W, Wagner S, Kerkau S, Dichgans J, Tonn J C, Weller M

Abstract excerpt

Malignant progression in gliomas is correlated with increased migratory capacity which involves metalloproteolytic activity. Here, we report that ectopic expression of BCL-2 in two malignant glioma sublines markedly promoted glioma cell migration from spheroids and invasion into Matrigel-coated membranes. Invasion of fetal rat-brain aggregates was enhanced by BCL-2. Zymography revealed activation of matrix...

Topics

Animals
Brain Neoplasms
Cell Movement
Down-Regulation
Gelatinases
Gene Transfer Techniques
Glioma
Humans
Matrix Metalloproteinase 2
Metalloendopeptidases
Neoplasm Invasiveness
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proto-Oncogene Proteins c-bcl-2

Rats

Spheroids, Cellular

Tissue Inhibitor of Metalloproteinase-2

Tumor Cells, Cultured

Up-Regulation

Source

Open in PubMed

Identifiers

PMID: 9872414
DOI: 10.1016/s0014-5793(98)01494-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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