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Article

BCL-2 promotes migration and invasiveness of human glioma cells.

FEBS letters - 4 Dec 1998

Wick W, Wagner S, Kerkau S, Dichgans J, Tonn J C, Weller M

Abstract excerpt

Malignant progression in gliomas is correlated with increased migratory capacity which involves metalloproteolytic activity. Here, we report that ectopic expression of BCL-2 in two malignant glioma sublines markedly promoted glioma cell migration from spheroids and invasion into Matrigel-coated membranes. Invasion of fetal rat-brain aggregates was enhanced by BCL-2. Zymography revealed activation of matrix...

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Source

Identifiers

PMID: 9872414
DOI: 10.1016/s0014-5793(98)01494-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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