Article
Loss of heterozygosity and overexpression of p53 gene in human primary prostatic adenocarcinoma.
Diagnostic molecular pathology : the American journal of surgical pathology, part B - 1 Dec 1994
Fan K, Dao D D, Schutz M, Fink L M
Abstract excerpt
We have examined the loss of heterozygosity (LOH) of codon 72 and evaluated the overexpression of the tumor suppressor gene p53 in 43 primary human prostatic adenocarcinomas (PC). DNA from tumors and normal tissues were extracted from radical prostatectomy specimens. LOH was determined by restric...
Topics
- Adenocarcinoma
- Base Sequence
- Codon
- Endonucleases
- Fluorescent Antibody Technique
- Gene Deletion
- Gene Expression
- Gene Expression Regulation, Neoplastic
- Genes, p53
- Heterozygote
- Humans
- Male
- Molecular Sequence Data
- Mutation
- Polymorphism, Restriction Fragment Length
- Prostate
- Prostatic Neoplasms
- Tumor Cells, Cultured