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Article

Somatic TP53 Mutations in the Era of Genome Sequencing.

Cold Spring Harbor perspectives in medicine - 1 Nov 2016

Hainaut Pierre, Pfeifer Gerd P

Abstract excerpt

Amid the complexity of genetic alterations in human cancer, TP53 mutation appears as an almost invariant component, representing by far the most frequent genetic alteration overall. Compared with previous targeted sequencing studies, recent integrated genomics studies offer a less biased view of TP53 mutation patterns, revealing that >20% of mutations occur outside the DNA-binding domain. Among the 12 mutations...

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Identifiers

PMID: 27503997
DOI: 10.1101/cshperspect.a026179
PMCID: PMC5088513

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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