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Article

Termination-altering mutations in the second-largest subunit of yeast RNA polymerase III.

Molecular and cellular biology - 1 Mar 1995

Shaaban S A, Krupp B M, Hall B D

Abstract excerpt

In order to identify catalytically important amino acid changes within the second-largest subunit of yeast RNA polymerase III, we mutagenized selected regions of its gene (RET1) and devised in vivo assays for both increased and decreased transcription termination by this enzyme. Using as the reporter gene a mutant SUP4-o tRNA gene that in one case terminates prematurely and in the other case fails to terminate,...

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Identifiers

PMID: 7862140
DOI: 10.1128/MCB.15.3.1467
PMCID: PMC230371

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