Rit1, a tRNA backbone-modifying enzyme that mediates initiator and elongator tRNA discrimination.

doi:10.1016/0092-8674(94)90262-3

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Article

Rit1, a tRNA backbone-modifying enzyme that mediates initiator and elongator tRNA discrimination.

Cell - 4 Nov 1994

Aström S U, Byström A S

Abstract excerpt

Using a genetic screen in yeast aimed at identifying cellular factors involved in initiator and elongator methionine tRNA discrimination in the translational process, we have identified a mutation that abolish the requirement for elongator methionine tRNA. The gene affected, which we call the ribosylation of the initiator tRNA gene or RIT1, encodes a 2'-O-ribosyl phosphate transferase. This enzyme modifies...

Topics

Alleles
Amino Acid Sequence
Base Sequence
Chromosomes, Fungal
Cloning, Molecular
Molecular Sequence Data
Mutagenesis
Nucleic Acid Conformation
Pentosyltransferases
Peptide Chain Elongation, Translational
Peptide Chain Initiation, Translational

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Peptide Elongation Factor 1

Peptide Elongation Factors

Protein Biosynthesis

RNA Processing, Post-Transcriptional

RNA, Transfer, Met

Restriction Mapping

Saccharomyces cerevisiae

Source

Open in PubMed

Identifiers

PMID: 7954819
DOI: 10.1016/0092-8674(94)90262-3

Genes

RIT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7954819-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Rit1, a tRNA backbone-modifying enzyme that mediates initiator and elongator tRNA discrimination.PMID 7954819Read ↗

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