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Article

Mutational analysis of the hydrolytic activity of yeast RNA polymerase III.

The Journal of biological chemistry - 23 Jul 1999

Bobkova E V, Habib N, Alexander G, Hall B D

Abstract excerpt

For 25 mutant alleles of ret1, encoding the second largest subunit of yeast RNA polymerase III, we have studied the polymerase III nuclease activity, measuring both the total yield and dinucleotide product composition. Mutations affecting amino acids 309-325 gave slightly elevated nuclease activity. In region 367-376, two mutations gave 12-15-fold increased nuclease activity. Our results do not support the...

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PMID: 10409694
DOI: 10.1074/jbc.274.30.21342

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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