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MLKL deficiency protects against low-grade, sterile inflammation in aged mice

8 Feb 2023

Abstract excerpt

Abstract MLKL and RIPK3 are the core signaling proteins of the inflammatory cell death pathway, necroptosis, which is a known mediator and modifier of human disease. Necroptosis has been implicated in the progression of disease in almost every physiological system and recent reports suggest a role for necroptosis in aging. Here, we present the first comprehensive analysis of age-related histopathological and...

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PMID: 36755069
DOI: 10.1038/s41418-023-01121-4

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