Article
Single-cell analysis of the RhD blood type for use in preimplantation diagnosis in the prevention of severe hemolytic disease of the newborn.
American journal of obstetrics and gynecology - 1 Feb 1995
Van den Veyver I B, Chong S S, Cota J, Bennett P R, Fisk N M, Handyside A H, Cartron J P, Le Van Kim C, Colin Y, Snabes M C
Abstract excerpt
OBJECTIVE: Our purpose was to develop a molecular assay to determine the fetal RhD blood type on single diploid cells, including blastomeres. STUDY DESIGN: Polymerase chain reaction amplification of a 99 bp deoxyribonucleic acid fragment of the RhD gene or a 113 bp fragment from the RhCE gene was performed from 20 venous blood samples and 20 amniotic fluid samples and from 60 single-cultured lymphoblasts and 12...
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