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Sequence and Insertion Sites of Murine Melanoma-Associated Retrovirus

1 Nov 1999

Abstract excerpt

We previously showed that B16 melanoma cells produce ecotropic melanoma-associated retrovirus (MelARV) which encodes a melanoma-associated antigen recognized by MM2-9B6 monoclonal antibody. The biological significance of MelARV in melanoma formation remains unknown. We found that infection of normal melanocytes with MelARV resulted in malignant transformation. It is likely that MelARV emerged from the defective...

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PMID: 10516025
DOI: 10.1128/jvi.73.11.9178-9186.1999

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