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Article

Insertion mutation of the int-1 and int-2 loci by mouse mammary tumor virus in premalignant and malignant neoplasms from the GR mouse strain.

Journal of virology - 1 Apr 1990

Morris D W, Barry P A, Bradshaw H D, Cardiff R D

Abstract excerpt

Mouse mammary tumor virus (MMTV)-induced mammary adenocarcinomas can develop from several different premalignant precursors common in GR mice. Insertion mutagenesis of the mammary protooncogenes int-1 and int-2 was studied in this multistep system by analyzing samples from various stages of neoplastic development for novel int-1 and int-2 restriction fragments generated by MMTV provirus integration. int-1 and...

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Identifiers

PMID: 2157060
DOI: 10.1128/JVI.64.4.1794-1802.1990
PMCID: PMC249317

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