Insertion mutation of the int-1 and int-2 loci by mouse mammary tumor virus in premalignant and malignant neoplasms from the GR mouse strain.

doi:10.1128/JVI.64.4.1794-1802.1990

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Article

Insertion mutation of the int-1 and int-2 loci by mouse mammary tumor virus in premalignant and malignant neoplasms from the GR mouse strain.

Journal of virology - 1 Apr 1990

Morris D W, Barry P A, Bradshaw H D, Cardiff R D

Abstract excerpt

Mouse mammary tumor virus (MMTV)-induced mammary adenocarcinomas can develop from several different premalignant precursors common in GR mice. Insertion mutagenesis of the mammary protooncogenes int-1 and int-2 was studied in this multistep system by analyzing samples from various stages of neopl...

Topics

Animals
Blotting, Southern
Cloning, Molecular
DNA Transposable Elements
Female
Mammary Neoplasms, Experimental
Mammary Tumor Virus, Mouse
Mice
Mice, Inbred Strains
Mutation
Neoplasm Transplantation
Precancerous Conditions
Proto-Oncogenes
Restriction Mapping

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Identifiers

PMID: 2157060
DOI: 10.1128/JVI.64.4.1794-1802.1990
PMCID: PMC249317

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2157060-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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