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MMTV mouse models and the diagnostic values of MMTV-like sequences in human breast cancer

1 Jul 2009

Abstract excerpt

Mouse mammary tumor virus (MMTV) long terminal repeat (LTR)-driven transgenic mice are excellent models for breast cancer as they allow for the targeted expression of various oncogenes and growth factors in neoplastic transformation of mammary glands. Numerous MMTV-LTR-driven transgenic mouse models of breast cancer have been created in the past three decades, including MMTV-neu/ErbB2, cyclin D1, cyclin E, Ras,...

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PMID: 19580428
DOI: 10.1586/erm.09.31

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