HLA class II genotypes in Leber's hereditary optic neuropathy.

doi:10.1016/0022-510x(94)90272-0

Back to search

Article

HLA class II genotypes in Leber's hereditary optic neuropathy.

Journal of the neurological sciences - 1 Nov 1994

Govan G G, Smith P R, Kellar-Wood H, Schapira A H, Harding A E

Abstract excerpt

There is an association between Leber's hereditary optic neuropathy (LHON) and a multiple sclerosis-like illness, raising the possibility of autoimmune pathogenetic mechanisms in LHON. We therefore investigated the frequency of HLA-DR genotypes in members of 79 families with LHON, defined by the...

Topics

Alleles
DNA, Mitochondrial
Female
Genotype
Histocompatibility Antigens Class II
Humans
Male
Multiple Sclerosis
Mutation
Optic Atrophies, Hereditary

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.