Bilateral simultaneous optic neuropathy in adults: clinical, imaging, serological, and genetic studies.

doi:10.1136/jnnp.58.1.70

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Article

Bilateral simultaneous optic neuropathy in adults: clinical, imaging, serological, and genetic studies.

Journal of neurology, neurosurgery, and psychiatry - 1 Jan 1995

Morrissey S P, Borruat F X, Miller D H, Moseley I F, Sweeney M G, Govan G G, Kelly M A, Francis D A, Harding A E, McDonald W I

Abstract excerpt

To elucidate the cause(s) of acute or subacute bilateral simultaneous optic neuropathy (BSON) in adult life, a follow up study of 23 patients was performed with clinical assessment, brain MRI, HLA typing, and mitochondrial DNA analysis. The results of CSF electrophoresis were available from previous investigations in 11 patients. At follow up, five (22%) had developed clinically definite multiple sclerosis, four...

Topics

Adolescent
Adult
Aged
Alleles
Brain
DNA Probes, HLA
DNA, Mitochondrial
Female
Follow-Up Studies
Functional Laterality
Genome, Human

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Haplotypes

Humans

Immunoglobulin G

Magnetic Resonance Imaging

Male

Middle Aged

Multiple Sclerosis

Source

Open in PubMed Open full text

Identifiers

PMID: 7823072
DOI: 10.1136/jnnp.58.1.70
PMCID: PMC1073271

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7823072-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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