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Article

Involvement of glutamic acid 23 in the catalytic mechanism of T4 endonuclease V.

The Journal of biological chemistry - 10 Feb 1995

Manuel R C, Latham K A, Dodson M L, Lloyd R S

Abstract excerpt

Bacteriophage T4 endonuclease V has both pyrimidine dimer-specific DNA glycosylase and abasic (AP) lyase activities, which are sequential yet biochemically separable functions. Previous studies using chemical modification and site-directed mutagenesis techniques have shown that the catalytic activities are mediated through the alpha-amino group of the enzyme forming a covalent (imino) intermediate. However, in...

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PMID: 7852333
DOI: 10.1074/jbc.270.6.2652

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Involvement of glutamic acid 23 in the catalytic mechanism of T4 endonuclease V.PMID 7852333Read ↗

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Mutations in motif II of Escherichia coli DNA helicase II render the enzyme nonfunctional in both mismatch repair and excision repair with differential effects on the unwinding reaction.Semantic proximity Read ↗

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