Article
The E249K mutator mutant of DNA polymerase beta extends mispaired termini.
The Journal of biological chemistry - 10 Dec 1999
Kosa J L, Sweasy J B
Abstract excerpt
The DNA polymerase beta mutant enzyme, which is altered from glutamic acid to lysine at position 249, exhibits a mutator phenotype in primer extension assays and in the herpes simplex virus-thymidine kinase (HSV-tk) forward mutation assay. The basis for this loss of accuracy was investigated by measurement of misincorporation fidelity in single turnover conditions. For the four misincorporation reactions...
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