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Article

Reaction intermediates in the catalytic mechanism of Escherichia coli MutY DNA glycosylase.

The Journal of biological chemistry - 5 Nov 2004

Manuel Raymond C, Hitomi Kenichi, Arvai Andrew S, House Paul G, Kurtz Andrew J, Dodson M L, McCullough Amanda K, Tainer John A, Lloyd R Stephen

Abstract excerpt

The Escherichia coli adenine DNA glycosylase, MutY, plays an important role in the maintenance of genomic stability by catalyzing the removal of adenine opposite 8-oxo-7,8-dihydroguanine or guanine in duplex DNA. Although the x-ray crystal structure of the catalytic domain of MutY revealed a mechanism for catalysis of the glycosyl bond, it appeared that several opportunistically positioned lysine side chains...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15326180
DOI: 10.1074/jbc.M403944200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Reaction intermediates in the catalytic mechanism of Escherichia coli MutY DNA glycosylase.PMID 15326180Read ↗

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