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Article

The interaction of T4 endonuclease V E23Q mutant with thymine dimer- and tetrahydrofuran-containing DNA.

Journal of bacteriology - 1 Sept 1995

Latham K A, Manuel R C, Lloyd R S

Abstract excerpt

The interaction between endonuclease V, the cyclobutane pyrimidine dimer-specific N-glycosylase/abasic lyase from bacteriophage T4, and DNA was investigated by DNase I footprinting methods. The catalytically inactive mutant E23Q was found to interact with a smaller region of DNA at the abasic site analog, tetrahydrofuran, than at a thymine dimer site. Like the wild-type enzyme, the mutant contacted the DNA...

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Identifiers

PMID: 7665500
DOI: 10.1128/jb.177.17.5166-5168.1995
PMCID: PMC177301

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Source receipt: pubmed, retrieved 7 Sept 2026.

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