Article
Mutational analysis of the double-stranded RNA (dsRNA) binding domain of the dsRNA-activated protein kinase, PKR.
The Journal of biological chemistry - 10 Feb 1995
McMillan N A, Carpick B W, Hollis B, Toone W M, Zamanian-Daryoush M, Williams B R
Abstract excerpt
The interferon-induced, double-stranded RNA (dsRNA)-dependent protein kinase, PKR, is an inhibitor of translation and has antiviral, antiproliferative, and antitumor properties. Previously, the dsRNA binding domain had been located within the N-terminal region of PKR and subsequently shown to inc...
Topics
- 3T3 Cells
- Alanine
- Amino Acid Sequence
- Animals
- Base Sequence
- Cloning, Molecular
- Humans
- Mice
- Molecular Sequence Data
- Mutagenesis
- Mutation
- Protein Binding
- Protein Serine-Threonine Kinases
- RNA, Double-Stranded
- Saccharomyces cerevisiae
- Sequence Homology, Amino Acid
- eIF-2 Kinase