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Article

Site-specific modification and RNA crosslinking of the RNA-binding domain of PKR.

Nucleic acids research - 1 May 2000

Spanggord R J, Beal P A

Abstract excerpt

RNA-dependent protein kinase (PKR) is an interferon-induced, RNA-activated enzyme that phosphorylates and inhibits the function of the translation initiation factor eIF-2. PKR is activated in vitro by binding RNA molecules with extensive duplex structure. To further define the nature of the RNA regulation of PKR, we have prepared and characterized site-specifically modified proteins consisting of the PKR 20 kDa...

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Identifiers

PMID: 10756189
DOI: 10.1093/nar/28.9.1899
PMCID: PMC103299

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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