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Article

Influenza A Virus Virulence Depends on Two Amino Acids in the N-Terminal Domain of Its NS1 Protein To Facilitate Inhibition of the RNA-Dependent Protein Kinase PKR.

Journal of virology - 15 May 2017

Schierhorn Kristina L, Jolmes Fabian, Bespalowa Julia, Saenger Sandra, Peteranderl Christin, Dzieciolowski Julia, Mielke Maja, Budt Matthias, Pleschka Stephan, Herrmann Andreas, Herold Susanne, Wolff Thorsten

Abstract excerpt

The RNA-dependent protein kinase (PKR) has broad antiviral activity inducing translational shutdown of viral and cellular genes and is therefore targeted by various viral proteins to facilitate pathogen propagation. The pleiotropic NS1 protein of influenza A virus acts as silencer of PKR activation and ensures high-level viral replication and virulence. However, the exact manner of this inhibition remains...

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Identifiers

PMID: 28250123
DOI: 10.1128/JVI.00198-17
PMCID: PMC5411612

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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