Article
PKR activity modulation by phosphomimetic mutations of serine residues located three aminoacids upstream of double-stranded RNA binding motifs.
Scientific reports - 28 Apr 2021
Cesaro Teresa, Hayashi Yohei, Borghese Fabian, Vertommen Didier, Wavreil Fanny, Michiels Thomas
Abstract excerpt
Eukaryotic translation initiation factor 2 alpha kinase 2 (EIF2AK2), better known as PKR, plays a key role in the response to viral infections and cellular homeostasis by regulating mRNA translation. Upon binding dsRNA, PKR is activated through homodimerization and subsequent autophosphorylation on residues Thr446 and Thr451. In this study, we identified a novel PKR phosphorylation site, Ser6, located 3...
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