Functional consequences of proline mutations in the putative transmembrane segments 6 and 10 of the glucose transporter GLUT1.

doi:10.1111/j.1432-1033.1995.tb20409.x

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Article

Functional consequences of proline mutations in the putative transmembrane segments 6 and 10 of the glucose transporter GLUT1.

European journal of biochemistry - 15 Jan 1995

Wellner M, Monden I, Mueckler M M, Keller K

Abstract excerpt

Proline residues are thought to play a characteristic structural and/or dynamic role in various membrane proteins [Williams, K.A. & Deber, C.M. (1991) Biochemistry 30, 8919-8923]. By use of site-directed mutagenesis and functional expression of mutant glucose transporters in Xenopus oocytes, we i...

Topics

Animals
Cell Membrane
DNA, Complementary
Glucose Transporter Type 1
Humans
Monosaccharide Transport Proteins
Mutation
Proline
Xenopus

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