Article
Transmembrane segment 3 of the Glut1 glucose transporter is an outer helix.
The Journal of biological chemistry - 5 Nov 2004
Mueckler Mike, Roach William, Makepeace Carol
Abstract excerpt
A model has been proposed for the structure of the Glut1 glucose transporter based on the results of mutagenesis studies and homology modeling in which eight transmembrane segments form an inner helical bundle surrounded by four outer helices. The role of transmembrane segment 3 in this structural model was investigated using cysteine-scanning mutagenesis in conjunction with the membrane-impermeant,...
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