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Article

Sequence conservation in Ig-like domains: the role of highly conserved proline residues in the fibronectin type III superfamily.

Journal of molecular biology - 10 May 2002

Steward Annette, Adhya Sima, Clarke Jane

Abstract excerpt

The role of conserved proline residues in fibronectin type III (fnIII) domains is investigated. Surprisingly, none of the standard set of explanations for residue conservation applies. The proline residues are not apparently conserved for function, or stability, or to nucleate folding, or to promote stabilising interactions across domain boundaries. However, when the most highly conserved proline residues are...

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Identifiers

PMID: 12054791
DOI: 10.1016/S0022-2836(02)00184-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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