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Article

Functional consequences of proline mutations in the predicted transmembrane domain of P-glycoprotein.

1 Feb 1993

Abstract excerpt

Site-directed mutagenesis was used to investigate whether phenylalanine residues in predicted transmembrane sequences play essential roles in the function of human P-glycoprotein. Mutant cDNAs, in which codons for each of the 31 phenylalanine residues were changed to alanine, were expressed in mouse NIH 3T3 cells and analyzed with respect to their ability to confer resistance to various drugs. Mutation of either...

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PMID: 8094081
DOI: 10.1016/s0021-9258(18)53670-x

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