Article
Induction of genotoxic effects by chlorohydroxyfuranones, byproducts of water disinfection, in E. coli K-12 cells recovered from various organs of mice.
Environmental and molecular mutagenesis - 1 Jan 1994
Fekadu K, Parzefall W, Kronberg L, Franzen R, Schulte-Hermann R, Knasmüller S
Abstract excerpt
The genotoxic effects of three chlorohydroxyfuranones (CHFs), 3-chloro-4-(dichloromethyl)-5-hydroxy-2[5H]-furanone (MX), 3-chloro-4-(chloromethyl)-5-hydroxy-2[5H]furanone (CMCF) and 3,4,-dichloro-5-hydroxy-2[5H]furanone (MCA), which are formed as byproducts of water disinfection with chlorine, were investigated in bacterial differential DNA repair assays in vitro and in animal-mediated assays in vivo. As...
Topics
- Analysis of Variance
- Animals
- Biotransformation
- Cell Line
- DNA Damage
- DNA Repair
- DNA, Bacterial
- Digestive System
- Escherichia coli
- Furans
- Genes, Tumor Suppressor