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Article

Effects of phenyl derivatives of dihydropyrazines with ability to generate radical species on Escherichia coli.

Biological & pharmaceutical bulletin - 1 Sept 2007

Takeda Osamu, Takechi Shinji, Ito Shigeru, Omori Hisamitsu, Katoh Takahiko, Yamaguchi Tadatoshi

Abstract excerpt

Phenyl-substituted dihydropyrazines (Ph-DHPs) are derivatives of 2,3-dihydro-5,6-dimethylpyrazine (Me-DHP). Upon the addition of Cu(2+), Me-DHP inhibits the growth of Escherichia coli by generating hydroxyl and carbon-centered radicals that cause DNA strand breakage. Here, we investigated the toxic effect of Ph-DHPs in several DNA repair-deficient or detoxifying enzyme-deficient mutant strains. Ph-DHPs caused...

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PMID: 17827717
DOI: 10.1248/bpb.30.1663

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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