Article
Role of free radicals produced during the metabolism of mitomycin C in Escherichia coli inactivation.
Xenobiotica; the fate of foreign compounds in biological systems - 1 May 1990
Schiavano G F, Brandi G, Salvaggio L, Cattabeni F C, Cantoni O
Abstract excerpt
1. The primary objective of this study was to assess whether reactive oxygen species produced during the metabolism of mitomycin C are responsible for, or contribute to, the induction of the cytotoxic response. 2. Escherichia coli wild-type and superoxide dismutase mutants were grown either anoxically or euoxically, in K medium or minimal glucose medium, and treated with mitomycin C in K medium or M9 salts. The...
Topics
- Dimethyl Sulfoxide
- Escherichia coli
- Ethanol
- Free Radicals
- Hydroxides
- Hydroxyl Radical
- Mitomycin
- Mitomycins
- Mutation
- Oxygen
- Superoxide Dismutase