Article
Failure of imprinting at Igf-2: two models of mutation-selection balance.
American journal of human genetics - 1 Feb 1995
Spencer H G, Williams M J
Abstract excerpt
The failure of maternal imprinting at the insulin-like growth factor II (Igf-2) locus predisposes individuals to several clinical conditions, including Wilms tumor. Having two functional Igf-2 genes, therefore, is selectively disadvantageous, and the condition is probably maintained in human populations by recurrent mutation. We propose two models that predict the expected frequency of functionally diploid...
Topics
- Diploidy
- Female
- Gene Frequency
- Genes, Recessive
- Genomic Imprinting
- Homozygote
- Humans
- Insulin-Like Growth Factor II
- Models, Genetic
- Mutation
- Selection, Genetic
- Wilms Tumor