Maternal transmission of a humanised Igf2r allele results in an Igf2 dependent hypomorphic and non-viable growth phenotype.

doi:10.1371/journal.pone.0057270

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Article

Maternal transmission of a humanised Igf2r allele results in an Igf2 dependent hypomorphic and non-viable growth phenotype.

PloS one - 1 Jan 2013

Hughes Jennifer, Frago Susana, Bühnemann Claudia, Carter Emma J, Hassan A Bassim

Abstract excerpt

The cation independent mannose 6-phosphate/insulin-like growth factor 2 receptor (IGF2R) functions in the transportation and regulation of insulin-like growth factor 2 (IGF2) and mannose 6-phosphate modified proteins. The relative and specific titration of IGF2 by high affinity binding of IGF2R represents a mechanism that supports the parental conflict theory of genomic imprinting. Imprinting of Igf2 (paternal...

Topics

Animals
Female
Genomic Imprinting
Insulin-Like Growth Factor II
Male
Mice
Phenotype
Receptors, Somatomedin

Source

Open in PubMed Open full text

Identifiers

PMID: 23468951
DOI: 10.1371/journal.pone.0057270
PMCID: PMC3585325

Genes

IGF2

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