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Article

Population genetic consequences of the fragile-X syndrome, based on the X-inactivation imprinting model.

American journal of human genetics - 1 Mar 1990

Sved J A, Laird C D

Abstract excerpt

We have examined the population genetic consequences of the model of Laird (Genetics 117:587-599, 1987) in which the fragile-X syndrome is caused by "imprinting" of a mutant chromosome. The imprinting event in this model results from a block to reactivation of an inactive X chromosome prior to oogenesis. If it is assumed that males carrying the imprinted chromosome never reproduce, the frequencies of females and...

Topics

Dosage Compensation, Genetic
Female
Fragile X Syndrome
Gene Frequency
Genotype
Humans
Male
Mathematics
Models, Genetic
Mutation
Sex Chromosome Aberrations

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 2309697
PMCID: PMC1683633

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2309697-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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