Article

Sequence variants affect the genome-wide rate of germline microsatellite mutations

2022-06-29

Abstract excerpt

<title>Abstract</title> <p>Microsatellites are polymorphic tracts of short tandem repeats (STRs) with one to six base-pair (bp) motifs and are some of the most polymorphic markers in the genome. Using 6,084 Icelandic parent-offspring trios we estimate 63.7 (95% CI: 61.9–65.4) microsatellite de novo mutations (mDNMs) per offspring per generation. Paternal mDNMs occur at longer repeats, while maternal mDNMs affect...

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Literature Corpus work: 27813b67-94ec-52ad-a04d-fd11ea001f03
DOI: 10.21203/rs.3.rs-1716464/v1

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