Article
Transfection of the c-myc oncogene into normal Epstein-Barr virus-harboring B cells results in new phenotypic and functional features resembling those of Burkitt lymphoma cells and normal centroblasts.
The Journal of experimental medicine - 1 Feb 1995
Cutrona G, Ulivi M, Fais F, Roncella S, Ferrarini M
Abstract excerpt
Activated c-myc gene was introduced into the cells of three normal Epstein-Barr virus (EBV)-positive lymphoblastoid B cell lines (LCL). The cells were monitored for the appearance of new phenotypic and functional features compared with the control LCL cells transfected with plasmid that did not contain the c-myc gene. The LCL-expressing c-myc constitutively did not arrest growth in low serum concentration....
Topics
- ADP-ribosyl Cyclase
- ADP-ribosyl Cyclase 1
- Antigens, CD
- Antigens, Differentiation
- Apoptosis
- B-Lymphocytes
- Base Sequence
- Burkitt Lymphoma
- Cell Differentiation
- DNA Primers