Article
c-MYC overexpression in Ba/F3 cells simultaneously elicits genomic instability and apoptosis.
Oncogene - 2 May 2002
Fest Thierry, Mougey Virginie, Dalstein Véronique, Hagerty Marlon, Milette Danielle, Silva Santiago, Mai Sabine
Abstract excerpt
Overexpression of c-Myc in tumors is usually associated with cell proliferation and increased susceptibility to apoptosis. Concomitantly, c-Myc contributes to tumorigenesis by its ability to destabilize the cellular genome. Here, we examined whether c-Myc induces genomic instability and apoptosis in c-Myc-activated cells. Wild-type Myc (wt-Myc) and two mutated Myc myc box II proteins (mt-Myc) were overexpressed...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.