Article
Genomic variations in the hepatitis B core gene: a possible factor influencing response to interferon alfa treatment.
Gastroenterology - 1 Feb 1995
Naoumov N V, Thomas M G, Mason A L, Chokshi S, Bodicky C J, Farzaneh F, Williams R, Perrillo R P
Abstract excerpt
BACKGROUND/AIMS: Interferon treatment causes a sustained loss of virus replication only in a proportion of patients with chronic hepatitis B. This study investigated whether genomic variations in the precore/core gene of hepatitis B virus affect the response to interferon alfa. METHODS: The precore/core region was sequenced in 46 serum samples obtained before, during, and after interferon treatment of 12...
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