Genomic variations in the hepatitis B core gene: a possible factor influencing response to interferon alfa treatment.

doi:10.1016/0016-5085(95)90080-2

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Article

Genomic variations in the hepatitis B core gene: a possible factor influencing response to interferon alfa treatment.

Gastroenterology - 1 Feb 1995

Naoumov N V, Thomas M G, Mason A L, Chokshi S, Bodicky C J, Farzaneh F, Williams R, Perrillo R P

Abstract excerpt

BACKGROUND/AIMS: Interferon treatment causes a sustained loss of virus replication only in a proportion of patients with chronic hepatitis B. This study investigated whether genomic variations in the precore/core gene of hepatitis B virus affect the response to interferon alfa. METHODS: The precore/core region was sequenced in 46 serum samples obtained before, during, and after interferon treatment of 12...

Topics

Adult
Aged
Amino Acid Sequence
Chronic Disease
Drug Resistance
Female
Genes, Viral
Hepatitis B
Hepatitis B virus
Humans
Interferon-alpha

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Longitudinal Studies

Male

Middle Aged

Molecular Sequence Data

Mutation

Treatment Outcome

Viral Core Proteins

Source

Open in PubMed

Identifiers

PMID: 7835593
DOI: 10.1016/0016-5085(95)90080-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7835593-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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