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Article

Genomic variations in precore and cytotoxic T lymphocyte regions in chronic hepatitis B in relationship to interferon responsiveness.

Liver - 1 Apr 2000

Shindo M, Okuno T

Abstract excerpt

AIMS: Treatment of chronic hepatitis B patients with interferon (IFN) alpha results in a sustained loss of viral replication in as many as 20-40% of cases. The resistance to antiviral treatment by some viruses is due to positive selection of variants harboring mutations that confer resistance. An HBV variant with a stop codon in the precore region (A1896 HBV) has been reported to be associated with the response...

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Share to Cytotoxicity, Immunologic
Share to Genome, Viral
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hepatitis B Core Antigens

Share to Hepatitis B virus

Share to Interferon-alpha

Share to Interferon alpha-2

Share to T-Lymphocytes, Cytotoxic

Source

Identifiers

PMID: 10847482
DOI: 10.1034/j.1600-0676.2000.020002136.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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