Article
Retinoid kinetics in eye tissues of VPP transgenic mice and their normal littermates.
Investigative ophthalmology & visual science - 1 May 1999
Qtaishat N M, Okajima T I, Li S, Naash M I, Pepperberg D R
Abstract excerpt
PURPOSE: VPP mice, which possess a mutant transgene for opsin (V20G, P23H, P27L), exhibit a progressive rod degeneration that resembles one form of human autosomal dominant retinitis pigmentosa. In the present study the association of the development of VPP rod degeneration with abnormal operation of the retinoid visual cycle was examined. METHODS: Dark-adapted VPP mice and normal littermates were anesthetized...
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