Article
Phenotypic characterization of second generation offspring of alcohol-sensitive ANT and alcohol-insensitive AT rat lines.
Alcohol (Fayetteville, N.Y.) - 1 Jan 2000
Tuominen K, Sarviharju M, Honkanen A, Korpi E R
Abstract excerpt
The alcohol-sensitive ANT and the alcohol-insensitive AT rat lines developed by selective breeding for differential sensitivity to motor impairment on the tilting plane by a moderate ethanol dose (2 g/kg, IP), were cross-bred to produce second generation (F2) offspring to study phenotypic correlations between various behavioral and biochemical properties and the degree of initial alcohol sensitivity in the...
Topics
- Animals
- Behavior, Animal
- Corpus Striatum
- Corticosterone
- Dopamine
- Drug Tolerance
- Ethanol
- Motor Skills
- Phenotype
- Rats
