Article
Selection for high alcohol preference drinking in mice results in heightened sensitivity and rapid development of acute functional tolerance to alcohol's ataxic effects.
Genes, brain, and behavior - 1 Feb 2013
Fritz B M, Grahame N J, Boehm S L
Abstract excerpt
Propensity to develop acute functional (or within session) tolerance to alcohol (ethanol) may influence the amount of alcohol consumed, with higher drinking associated with greater acute functional tolerance (AFT). The goal of this study was to assess this potential correlated response between alcohol preference and AFT in second and third replicate lines of mice selectively bred for high (HAP2 and HAP3) and low...
Topics
- Alcohol Drinking
- Alcoholic Intoxication
- Alcoholism
- Animals
- Behavior, Animal
- Ethanol
- Female
- Gait Ataxia
- Genetic Predisposition to Disease
- Male
- Mice
- Mice, Inbred Strains
- Selection, Genetic
- Species Specificity