Article
Short-term selection for high and low ethanol intake yields differential sensitivity to ethanol's motivational effects and anxiety-like responses in adolescent Wistar rats.
Progress in neuro-psychopharmacology & biological psychiatry - 3 Oct 2017
Fernández Macarena Soledad, Báez Bárbara, Bordón Ana, Espinosa Laura, Martínez Eliana, Pautassi Ricardo Marcos
Abstract excerpt
Alcohol use disorders are modulated by genetic factors, but the identification of specific genes and their concomitant biological changes that are associated with a higher risk for these disorders has proven difficult. Alterations in the sensitivity to the motivational effects of ethanol may be one way by which genes modulate the initiation and escalation of ethanol intake. Rats and mice have been selectively...
Topics
- Alcohol-Related Disorders
- Animals
- Anxiety
- Central Nervous System Depressants
- Ethanol
- Feeding Behavior
- Female
- Genetic Predisposition to Disease
- Male
- Motivation
- Motor Activity
- Phenotype
- Rats, Wistar