Article
Molecular characterization of carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria in Saccharomyces cerevisiae and identification of a plasma membrane carnitine transporter, Agp2p.
The EMBO journal - 1 Nov 1999
van Roermund C W, Hettema E H, van den Berg M, Tabak H F, Wanders R J
Abstract excerpt
In Saccharomyces cerevisiae, beta-oxidation of fatty acids is confined to peroxisomes. The acetyl-CoA produced has to be transported from the peroxisomes via the cytoplasm to the mitochondrial matrix in order to be degraded to CO(2) and H(2)O. Two pathways for the transport of acetyl-CoA to the mitochondria have been proposed. The first involves peroxisomal conversion of acetyl-CoA into glyoxylate cycle...
Topics
- Acetyl Coenzyme A
- Amino Acid Transport Systems
- Biological Transport
- Carnitine
- Carnitine Acyltransferases
- Carnitine O-Acetyltransferase
- Carrier Proteins
- Cell Membrane
- Cloning, Molecular
- Fungal Proteins