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Article

Development of the yeast Pichia pastoris as a model organism for a genetic and molecular analysis of peroxisome assembly.

Yeast (Chichester, England) - 1 Aug 1992

Gould S J, McCollum D, Spong A P, Heyman J A, Subramani S

Abstract excerpt

We describe the isolation of mutants of the yeast Pichia pastoris that are deficient in peroxisome assembly (pas). These mutants of P. pastoris can be identified solely by their inability to grow on methanol and oleic acid, the utilization of which requires peroxisomal enzymes, and are defined by the absence of normal peroxisomes as judged by electron microscopy and biochemical fractionation experiments. These...

Topics

Biological Transport
Culture Media
DNA, Fungal
Genetic Vectors
Genomic Library
Methanol
Microbodies
Models, Molecular
Molecular Sequence Data
Mutation
Pichia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Species Specificity

Subcellular Fractions

Source

Identifiers

PMID: 1441741
DOI: 10.1002/yea.320080805

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1441741-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Development of the yeast Pichia pastoris as a model organism for a genetic and molecular analysis of peroxisome assembly.PMID 1441741Read ↗

An efficient screen for peroxisome-deficient mutants of Pichia pastoris.Semantic proximity Read ↗

Isolation and characterization of Pas2p, a peroxisomal membrane protein essential for peroxisome biogenesis in the methylotrophic yeast Pichia pastoris.Semantic proximity Read ↗

Positive selection of novel peroxisome biogenesis-defective mutants of the yeast Pichia pastoris.Semantic proximity Read ↗

The Pichia pastoris PER6 gene product is a peroxisomal integral membrane protein essential for peroxisome biogenesis and has sequence similarity to the Zellweger syndrome protein PAF-1.Semantic proximity Read ↗

Pex22p of Pichia pastoris, essential for peroxisomal matrix protein import, anchors the ubiquitin-conjugating enzyme, Pex4p, on the peroxisomal membrane.Semantic proximity Read ↗

The pas8 mutant of Pichia pastoris exhibits the peroxisomal protein import deficiencies of Zellweger syndrome cells--the PAS8 protein binds to the COOH-terminal tripeptide peroxisomal targeting signal, and is a member of the TPR protein family.Semantic proximity Read ↗

Atg28, a novel coiled-coil protein involved in autophagic degradation of peroxisomes in the methylotrophic yeast Pichia pastoris.Semantic proximity Read ↗

The Pichia pastoris PAS4 gene encodes a ubiquitin-conjugating enzyme required for peroxisome assembly.Semantic proximity Read ↗

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An efficient positive selection procedure for the isolation of peroxisomal import and peroxisome assembly mutants of Saccharomyces cerevisiae.Semantic proximity Read ↗

Paz2 and 13 other <i>PAZ</i> gene products regulate vacuolar engulfment of peroxisomes during micropexophagySemantic proximity Read ↗

Sterol glucosyltransferases have different functional roles in Pichia pastoris and Yarrowia lipolytica.Semantic proximity Read ↗

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