Article
Peroxisomal Atg37 binds Atg30 or palmitoyl-CoA to regulate phagophore formation during pexophagy.
The Journal of cell biology - 17 Feb 2014
Nazarko Taras Y, Ozeki Katharine, Till Andreas, Ramakrishnan Geetha, Lotfi Pouya, Yan Mingda, Subramani Suresh
Abstract excerpt
Autophagy is a membrane trafficking pathway that sequesters proteins and organelles into autophagosomes. The selectivity of this pathway is determined by autophagy receptors, such as the Pichia pastoris autophagy-related protein 30 (Atg30), which controls the selective autophagy of peroxisomes (pexophagy) through the assembly of a receptor protein complex (RPC). However, how the pexophagic RPC is regulated for...
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