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Article

Mouse very long-chain acyl-CoA synthetase in X-linked adrenoleukodystrophy.

The Journal of biological chemistry - 9 Aug 2002

Heinzer Ann K, Kemp Stephan, Lu Jyh-Feng, Watkins Paul A, Smith Kirby D

Abstract excerpt

X-linked adrenoleukodystrophy (X-ALD) is a neurodegenerative disorder characterized by accumulation of very long-chain fatty acids (VLCFA). This accumulation has been attributed to decreased VLCFA beta-oxidation and peroxisomal very long-chain acyl-CoA synthetase (VLCS) activity. The X-ALD gene, ABCD1, encodes a peroxisomal membrane ATP binding cassette transporter, ALDP, that is hypothesized to affect VLCS...

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Identifiers

PMID: 12048192
DOI: 10.1074/jbc.M203053200

Genes

ABCD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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