Article
[The p53 gene and protein in bronchial carcinogenesis:from biological to clinical aspects].
Revue des maladies respiratoires - 1 Jan 1994
Zalcman G, Trédaniel J, Lechapt E, Lubin R, Soussi T, Hirsch A
Abstract excerpt
The p53 gene codes for a nuclear phosphoprotein which is capable of modulating the expression of certain genes implicated in the regulation of cell division. The mutation of an allele on the p53 gene with loss of the healthy allele, in different tissues such as lung, larynx, bladder, liver, skin,...
Topics
- Alleles
- Carcinoma, Bronchogenic
- Drug Resistance
- Gene Expression Regulation, Neoplastic
- Genes, p53
- Genetic Therapy
- Homozygote
- Humans
- Lung Neoplasms
- Mutation
- Prognosis
- Radiation Tolerance
- Risk Factors
- Smoking
- Tumor Suppressor Protein p53