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Article

The viroporin activity of the minor structural proteins VP2 and VP3 is required for SV40 propagation.

The Journal of biological chemistry - 25 Jan 2013

Giorda Kristina M, Raghava Smita, Zhang Macy W, Hebert Daniel N

Abstract excerpt

For nonenveloped viruses such as Simian Virus 40, the mechanism used to translocate viral components across membranes is poorly understood. Previous results indicated that the minor structural proteins, VP2 and VP3, might act as membrane proteins during infection. Here, purified VP2 and VP3 were found to form pores in host cell membranes. To identify possible membrane domains, individual hydrophobic domains from...

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Identifiers

PMID: 23223228
DOI: 10.1074/jbc.M112.428425
PMCID: PMC3554919

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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