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Article

A very late viral protein triggers the lytic release of SV40.

PLoS pathogens - 1 Jul 2007

Daniels Robert, Sadowicz Dorota, Hebert Daniel N

Abstract excerpt

How nonenveloped viruses such as simian virus 40 (SV40) trigger the lytic release of their progeny is poorly understood. Here, we demonstrate that SV40 expresses a novel later protein termed VP4 that triggers the timely lytic release of its progeny. Like VP3, VP4 synthesis initiates from a downstream AUG start codon within the VP2 transcript and localizes to the nucleus. However, VP4 expression occurs...

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Identifiers

PMID: 17658947
DOI: 10.1371/journal.ppat.0030098
PMCID: PMC1924868

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Source receipt: pubmed, retrieved 7 Sept 2026.

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