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Article

The role of mdr2 in manganese-bilirubin induced cholestasis in mice.

Toxicology letters - 14 Mar 2004

Akoume Marie-Yvonne, Tuchweber Beatriz, Plaa Gabriel L, Yousef Ibrahim M

Abstract excerpt

The pathogenesis of manganese-bilirubin (Mn-BR) induced cholestasis has only been studied in rats and is associated with alteration in the hepatic homeostasis of cholesterol and phospholipids. Multidrug resistance-2 (mdr2) transporter, which mediates excretion of these lipids, is suggested to be involved in this phenomenon. The present study was undertaken to examine if Mn-BR induced cholestasis is reproducible...

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Identifiers

PMID: 15019087
DOI: 10.1016/j.toxlet.2003.12.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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